Publications
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Sex might chiefly influence paraoxonase-1 (PON1) activity and its contribution to cardiovascular disease risk.Trentini A, Bellini T, Bonaccorsi G , Cavicchio C, Hanau S, Passaro A, Cervellati C. Sex difference: an important issue to consider in epidemiological and clinical studies dealing with serum paraoxonase-1. J Clin Biochem Nutr. 2019 May;64(3):250-256. doi: 10.3164/jcbn.18-73
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In cases with cleft lip/palate the sex does not influence the difference in genomic DNA methylation at cleft lip sides.Khan MFJ, Little J, Aleotti V, Mossey PA, Steegers-Theunissen RPM, Autelitano L, Meazzini MC, Ravaei A, Rubini M. LINE-1 methylation in cleft lip tissues: Influence of infant MTHFR c.677C>T genotype. Oral Dis. 2019 Jun 4. doi: 10.1111/odi.13136. |
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In children with cleft lip the electron microscopy of orbicularis oris muscle fibers reveals differences between males and females that could associate with the higher incidence of the malformation among males.Khan MFJ, Little J, Abelli L, Mossey PA, Autelitano L, Nag TC, Rubini M. Muscle fiber diameter assessment in cleft lip using image processing. Oral Dis. 2018 Apr;24(3):476-481. doi: 10.1111/odi.12790.10.1111/odi.12790 |
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Maternal-Origin-Effect of specific gene variants suggests a two-faced epigenetic role on in-utero leukemogenesis responsible for the different male/female ratio in childhood acute lymphoblastic leukemia phenotypes.Tisato V, Muggeo P, Lupiano T, Longo G, Serino ML, Grassi M, Arcamone E, Secchiero P, Zauli G, Santoro N, Gemmati D. Maternal Haplotypes in DHFR Promoter and MTHFR Gene in Tuning Childhood Acute Lymphoblastic Leukemia Onset Latency: Genetic/Epigenetic Mother/Child Dyad Study (GEMCDS). Genes. 2019 Aug 22;10(9). pii: E634. doi: 10.3390/genes10090634 |
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Female infertility due to intestinal adhesions requires costly in vitro fertilization procedures. Predictive inherited predispositions useful to early recognize those at risk females could help clinicians in establishing targeted prevention programs.Gemmati D, Occhionorelli S, Tisato V, Vigliano M, Longo G, Gonelli A, Sibilla MG, Serino ML, Zamboni P. Inherited genetic predispositions in F13A1 and F13B genes predict abdominal adhesion formation: identification of gender prognostic indicators. Sci Rep. 2018 Nov 16;8(1):16916. doi: 10.1038/s41598-018-35185-x |
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Females have the worst prognosis after heart attack. During ongoing infarction coagulation FXIII falls in blood levels and this is genetically determined. Females undergo to excessive consuming needing higher levels to preserve heart wall structure.Ansani L, Marchesini J, Pestelli G, Luisi GA, Scillitani G, Longo G, Milani D, Serino ML, Tisato V, Gemmati D. F13A1 Gene Variant (V34L) and Residual Circulating FXIIIA Levels Predict Short- and Long-Term Mortality in Acute Myocardial Infarction after Coronary Angioplasty. Int J Mol Sci. 2018 Sep 14;19(9). pii: E2766. doi: 10.3390/ijms19092766 |
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Males have higher iron levels compared to females, conversely among Alzheimer’s disease females reach men in levels and APOE gene results a key determinant in brain iron deposit differently contributing to cognitive decline between the two sexes.Tisato V, Zuliani G, Vigliano M, Longo G, Franchini E, Secchiero P, Zauli G, Paraboschi EM, Vikram Singh A, Serino ML, Ortolani B, Zurlo A, Bosi C, Greco A, Seripa D, Asselta R, Gemmati D. Gene-gene interactions among coding genes of iron-homeostasis proteins and APOE-alleles in cognitive impairment diseases. PLoS One. 2018 Mar 8;13(3):e0193867. doi: 10.1371/journal.pone.0193867 |
