QUANTITATIVE ANALISYS OF DRUG AND ANALYTICAL CHEMISTRY
Academic year and teacher
If you can't find the course description that you're looking for in the above list,
please see the following instructions >>
- Versione italiana
- Academic year
- 2022/2023
- Teacher
- BARBARA CACCIARI
- Credits
- 12
- Didactic period
- Primo Semestre
Training objectives
- ------------------------------------------------------------
Modulo: 23151 - CHIMICA ANALITICA
------------------------------------------------------------
To acquire the basic knowledge of analytical chemistry, with particular attention to chemical equilibria and volumetric analysis. To learn the operating principles of the main analytical instrumentation of a chemical laboratory and their applications. To acquire the basic notions of qualitative and quantitative analysis and know how to present and discuss on a statistical basis the experimental results.
------------------------------------------------------------
Modulo: 45828 - ANALISI QUANTITATIVA DEL FARMACO
------------------------------------------------------------
QUANTITATIVE DRUG ANALYSIS
The course has the aim to exercise the Student to perform the quantitative determinations, according to the law, on compounds reported in the italian and european pharmacopeia (XII Edition). One apply, to the execution of these determinations, analytical methods by theoretical principles - with the chemistry and the stoichiometry - and the practical applications. Volumetric and strumental methods are employed. Prerequisites
- ------------------------------------------------------------
Modulo: 23151 - CHIMICA ANALITICA
------------------------------------------------------------
Basic knowledge of physics and mathematics, in particular first- and second-degree equations, properties of logarithms, exponential notation, reading and discussing an xy scatter plot. Use of a pocket scientific calculator. Knowledge of the most common units of measurement. Good knowledge of general chemistry. In order to take the exam of the integrated course, the student must have taken the exams of General and Inorganic Chemistry and Mathematics and Computer Science + Physics.
------------------------------------------------------------
Modulo: 45828 - ANALISI QUANTITATIVA DEL FARMACO
------------------------------------------------------------
QUANTITATIVE DRUG ANALYSIS
Bases of General and Inorganic Chemistry, Analytic Chemistry and of Organic Chemistry. Course programme
- ------------------------------------------------------------
Modulo: 23151 - CHIMICA ANALITICA
------------------------------------------------------------
The analytical method; sampling and sample preparation; concentration measurement units; statistical analysis of the results of a series of measurements.
The equilibrium constant: solubility equilibria, definitions and calculations.
Acid-base equilibria: calculation of the pH of monoprotic and polyprotic acids and bases.
Buffer solutions.
Volumetric methods: definitions, operating modes and calculations.
Acid-base titrations: description of operating modes and calculation of pH at each titration point.
Argentometric, complexometric and redox titrations.
Galvanic cells, standard reduction potentials and the Nernst equation; reference and measuring electrodes.
Chromatographic techniques: theory, instrumentation and operating modes.
Numerical exercises in preparation for the exam.
------------------------------------------------------------
Modulo: 45828 - ANALISI QUANTITATIVA DEL FARMACO
------------------------------------------------------------
QUANTITATIVE DRUG ANALYSIS
INTRODUCTION to the PHARMACEUTICAL QUANTITATIVE ANALYSIS - Classification of the analytical methods. General operations. Calculation. Expressions of concentration.- BALANCES - Classification and weighting the sample - VOLUMETRIC ANALYSIS - Graduated apparatus. Types of titration. Standard solutions. Equivalent weight. Calculation in volumetric analysis. Volumetric equivalent.- ACID/BASE TITRATIONS in AQUEOUS SOLUTION - Titration curves. Equivalence point. Direct titration of strong acids and bases. Direct titration of weak acids and bases. Direct titration of polyprotic acid. Direct titration of salt of weak acid and base. Back titrations and blank determinations. Acid/base Indicators.- TITRATION in NON AQUEOUS SOLVENTS - Theory. Titration of organic acids, organic bases, and halogen salts of organic bases. OXIDATION/REDUCTION TITRATIONS - Introduction. Indicatotors. Determinations involving the use of potassium permanganate solution. Direct and indirect titrations with iodine.- COMPLEXOMETRIC TITRATIONS - Theory of complexometric analysis. Indicators. Direct and back-titration with disodium edetate.- POTENTIOMETRY - Introduction. Reference electrodes. Indicator electrodes. Titration acid/base by pH-meter.- SPECTROPHOTOMETRY - Introduction. Electronic transitions. Beer/Lambert law. Chromophores. Solvents. Instrumentation for Ultraviolet/Visible absorption. HPLC, basic principles of chromatogrphy. Quantitative applications. Didactic methods
- ------------------------------------------------------------
Modulo: 23151 - CHIMICA ANALITICA
------------------------------------------------------------
Theoretical lessons in the classroom (6 CFU = 48 hours) with the help of the blackboard and the projection of slides and videos on all the topics of the program.
------------------------------------------------------------
Modulo: 45828 - ANALISI QUANTITATIVA DEL FARMACO
------------------------------------------------------------
QUANTITATIVE DRUGS ANALYSIS
Lectures (16 h) and practical work in the laboratory (48 h). During the lectures, general principles of analytic methods and instructions for the practical work are explained through oral exposition with blackboard support . In particular:
(1 h) general introduction to the course: textbook, organization of the work in the laboratory, final evaluation
(2 h) generality of volumetric titrations
(4 h) Aqueous and not aqueous acidi-base titrations
(4 h) Oxido-reductive titrations
(1 h) Complessometric titrations
(4 h) Instrumental methods: potenziometry, spettroscopy UV-Vis, HPLC
The part in the laboratory consists in different single seat analysis illustrated during the lectures. The practical exercises have a span of 4h a day. 18 h dedicated to aqueous and not aqueous acid -base analysis; 16 h oxide-reductive analysis; 4 h complessometric analysis. The instrumental methods are applied with a support of a technician. 4 h dedicated to potenziometric analysis, 4h to UV-Vis spettrophotometric analysis and 2h to HPLC. Learning assessment procedures
- The examination consists in a written and oral tests, aimed to assess and measure a test-taker's knowledge, skill, and aptitude towards the whole content of the two teaching units.
The written part consists in three stoichiometry exercices for Analytical Chemistry unit, and an oral discussion about the laboratory work.
The final score accounts of the partial evaluation of the written and oral tests and of the quality of the practical part. Reference texts
- ------------------------------------------------------------
Modulo: 23151 - CHIMICA ANALITICA
------------------------------------------------------------
The reference text is as follows: D.C. Harris, "Chimica analitica quantitativa", Zanichelli, 3a ed. italiana, 2017.
For consultation the following texts are also recommended: D.A. Skoog, D.M. West, F.J. Holler, S.R. Crouch "Fundamentals of Analytical Chemistry", 2nd edition, EdiSES, 2005; R. Cozzi, P. Protti, T. Ruaro, Instrumental Chemical Analysis, Zanichelli, 1997.
The teacher will also provide students with the slides shown in class, in the form of handouts.
------------------------------------------------------------
Modulo: 45828 - ANALISI QUANTITATIVA DEL FARMACO
------------------------------------------------------------
QUANTITATIVE ANALYSIS OF DRUGS Unit
G.C.PORRETTA - Analisi di Preparazioni Farmaceutiche.Analisi Quantitativa(Vol. I e II)- CISU,
PCREPALDI, B. CACCIARI-Analisi Quantitativa di Principi Farmaceutici-Teoria e Pratica di Laboratorio- ISBN 978-88-3359-276-3 Edizioni Libreria Universitaria
