GENERAL PATHOLOGY
Academic year and teacher
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- Versione italiana
- Academic year
- 2017/2018
- Teacher
- FRANCESCO ZORZATO
- Credits
- 6
- Didactic period
- Secondo Semestre
- SSD
- MED/04
Training objectives
- Understanding of the main causes and mechanisms of disease, and the protective and/or pathogenetic role of the defense mechanisms of the organism (immune system, inflammation)
Prerequisites
- Basic notions of anatomy, biochemistry and physiology
Course programme
- 1) DISEASE AS RESULT OF HOMEOSTASIS DISTURBANCE
Definition of health and disease. Etiology and pathogenesis
2) GENETIC DISORDERS
The most common genetic disorders (hereditary anemias, cystic fibrosis)
Mitochondrial diseases
3) ENVIRONMENTAL FACTORS IN DISEASE
a) PHYSICAL INJURY
b) CHEMICAL INJURY
c) OBESITY AND DIET DEFICIENCIES
d) BACTERIAL TOXINS
4) CELLULAR INJURY
Mechanisms of injury at the cellular level, and patterns of tissue injury: reactive oxygen species (ROS) and hypoxia. Different types of cell death: apoptosis, authophagy and necrosis
5) IMMUNOPATHOLOGY
a) The immune system: B and T lymphocytes, primary and secondary immune responses, antibodies and cell-mediated responses, complement. Immunologic mechanisms of injury, with patterns of injury and major autoimmune diseases.
b) Inflammation: acute and chronic inflammation.
6) NEOPLASIA
Neoplastic disease, with illustrations of benign and malignant processes and their pathologic consequences. Epidemiology, microscopic and macroscopic properties, molecular basis, oncogenes and tumor-suppressor genes, neoplasia as multistage process.
7) PHYSIOLOGY OF TEMPERATURE REGULATION
- Heat production and heat loss.
- Fever and hyperthermia
8) PATHOPHYSIOLOGY OF CARDIOVASCULAR SYSTEM
- Thrombosis
- Infarction
- shock
- edema
- hypertension
9) PATHOPHYSIOLOGY OF BLOOD
- The blood and blood cells
- Classification of anemia
- The haemostatic mechanism
- Bleeding classification
10) PATHOPHYSIOLOGY OF ENDOCRINE SYSTEM
- diabetes mellitus
- hypo- and hyper-thyroidism
- disorders of the menstrual cycle
11) PATHOPHYSIOLOGY OF GASTROINTESTINAL SYSTEM
- diarrheas
- hepatitis
- cirrhosis
- clinical manifestation of hepatic diseases (yellow jaundice) Didactic methods
- Lecture
Learning assessment procedures
- Written examinations
Reference texts
- Patologia-Rubin-Casa editrice Ambrosiana
Patologia Robbins
Patologia- Generale Maino
