HAEMATOLOGY
Academic year and teacher
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- Versione italiana
- Academic year
- 2022/2023
- Teacher
- FRANCESCO CAVAZZINI
- Credits
- 6
- Didactic period
- Primo Semestre
- SSD
- MED/15
Training objectives
- Learning of the principles and techniques useful in recognizing blood components (cells and plasma proteins). Blood functions and recognition of the main alterations in cells ratios and number and morphology changing: Cytology investigations aimed in morphological, functional and number parameters. Ability in the correct interpretation of changes in the concentration of plasma proteins blood protein. Blood Coagulation cascade (factors and cofactors functions).
Recognition and detection of the main pathogenetic gene mutations in hematological malignancies, thrombophilia and hemophilia. Practical pharmacogenetics application.
The molecular Biology techniques in the Biomedical Labs (diagnosis, prognosis and drug monitoring; i.e. minimal residual disease) in haematological fields. Learning of the main techniques for the expression, synthesis and purification of the biological-recombinant drugs and directions for use. Learning of the main biologic-functional tests in Hematology. Prerequisites
- Knowledge of biology, genetics, molecular biology, chemistry, biochemistry
Course programme
- Blood, circulation, composition and function. Haemochrome and formula, cytology and blood function, blood coagulation, coagulation abnormalities (von Willebrandt disease, Haemophilia, Disseminated Intravascular Coagulation).
Blood cells disorders (anemia and policythemia); white cells disorders (leukocytosis and leucopenia, cjronic and acute leukemias); platets disorders (thrombocytosis and thrombocytopenia). Each disease will be discussed referring especially to blood tests and laboratory techniques necessary for the diagnosis and for monitoring minimal residual disease mutations Didactic methods
- Frontal lessons, using power point presentations and video-clips related to the specific topics day by day. In addition, a practical laboratory lesson is used to summarize the main subjects of the whole course of hematology at the end of the course
Learning assessment procedures
- Multiple Choiche Test with 31 questions (5 possible answers, only 1 correct).
The test will take place in presence.
Each correct answer corresponds to 1 point, without penalty for incorrect answers.
In order to exceed the written test there must be at least 18 correct answers.
Duration of the test will be approximately 40 minutes Reference texts
- Lectures slides
Dacie and Lewis Practical Haematology. S. Mitchell Lewis, Barbara J. Bain, Imelda Bates, Churchill Livingstone
