TECHNOLOGY OG THE RADIOFARMACEUTICALS FOR DIAGNOSIS AND THERAPY
Academic year and teacher
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- Versione italiana
- Academic year
- 2022/2023
- Teacher
- LICIA UCCELLI
- Credits
- 6
- Didactic period
- Primo Semestre
- SSD
- MED/36
Training objectives
- RADIOBIOLOGY
• Basic principles and primary effects of the interactions between ionizing radiation and living matter.
RADIOPROTECTION
• Main local and national regulations in the field of radiation protection for patients, operators and the population.
RADIOFARMACEUTICALS FOR DIAGNOSIS AND THERAPY
• Production and quality control of radionuclides and radiopharmaceuticals for diagnostic and therapeutic procedures. These aspects are mainly aimed at achieving a global vision of the production process of radiopharmaceuticals for clinical and experimental nuclear medical use; a further objective concerns the knowledge of the environments and instrumentation dedicated to clinical and experimental radiopharmaceutical production; a further objective is represented by the knowledge of the current legislation in the radiopharmaceutical field.
The main skills (i.e. the ability to apply the knowledge acquired) will be represented by knowing and understanding: (a) the dynamics of the preparation and quality control processes of radiopharmaceuticals for clinical and experimental use; (b) their application with a correct methodological approach inspired by the principles of radiobiology and radiation protection. Prerequisites
- Basics of: Biology; Physics; General and Inorganic Chemistry; Organic Chemistry and Analytical Chemistry.
Course programme
- Radioactivity: decay and measurement
Radiobiology
Radiation protection
Radioisotopes and Radiopharmaceuticals for diagnostics and therapeutics use: production and quality control methods
Radiopharmacy, equipment and tools
Radiopharmaceuticals labeled with single photon emitters
Radiopharmaceuticals labeled with positron emitters
Radiopharmaceuticals for therapy
Regulatory aspects Didactic methods
- 48 hours of lessons delivered in blended mode (recorded lessons, online or face-to-face focus groups) with the use of self-produced material (slides and / or videos)
Learning assessment procedures
- The objective of the exam is to verify the level of achievement of the previously indicated training objectives.
The exam consists of a written quiz test (33 multiple choice quizzes, 4 answers, one exact) on all the topics covered in the course and divided as follows: 6 Radiobiology questions; 11 Radioprotection questions and 16 Radiopharmaceuticals questions.
The test aims to assess the student's knowledge and understanding of the topics covered. The estimated time for the test is 40 minutes. The evaluation criteria for the questions is as follows: +1 point for each correct answer, 0 points for each wrong or not given answer. To pass the exam it is necessary to acquire a minimum overall score of 18 out of 30. A score higher than 30 allows the achievement of “laude”. Reference texts
- RADIOBIOLOGY AND RADIOPROTECTION.
• Martinenghi C., Fossati V., Radiobiologia, Ed. Raffaello Cortina, Milano
• Orecchia R., Lucignani G., Tosi G., Elementi di Radiobiologia Clinica e Radioprotezione, Ed. Archimedica 2001
RADIOPHARMACEUTICALS FOR DIAGNOSTICS AND THERAPY
• G.Lucignani, La Qualità nelle Preparazione dei Radiofarmaci; Edito da Springer, 2011
• G. Lucignani, Sperimentazione e Registrazione di Radiofarmaci; Edito da Springer, 2013
• S. Todde e S. Boschi, Compendio di Radiochimica e Radiofarmacia; Edito da Minerva Medica, 2020
