MOLECULAR AND FUNCTIONAL BASES OF LIFE
Academic year and teacher
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- Versione italiana
- Academic year
- 2022/2023
- Teacher
- DONATO GEMMATI
- Credits
- 8
- Didactic period
- Primo Semestre
Training objectives
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Modulo: 000061/1 - BIOCHIMICA
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Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines.
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Modulo: 009824/2 - CHIMICA MEDICA
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MEDICAL CHEMISTRY AND BIOCHEMISTRY
Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines. Use of simple calculation to perform dilution of drugs.
APPLIED BIOLOGY
Provide fundamental knowledge on biological macromolecules, structure and function of the cell components, replication and transcription of DNA, RNA translation.
MEDICAL GENETICS
To provide the fundamental knowledge on the genetic basis of the transmission of hereditary characters.
To analyze the molecular mechanisms causing hereditary genetic diseases in individuals and families.
Understanding the inheritance mechanism of inherited genetic diseases by pedigree analysis.
APPLIED PHYSISC
Basic physical training able to tackle elementary solutions of physical problems in the curriculum of the degree course.
MEDICAL STATISTICS
The course is intended to teach basic concepts of descriptive and inferential statistics applied to the biomedical field.
The teaching program is designed to providing the basic knowledge for interpreting the main statistical results reported in scientific evidence.
COMPUTER SCIENCE AND SEMIAR OF COMPUTER SCIENCE
Provide the basics that make up the hardware and software elements of a computer system.
Learn to use an electronic spreadsheet as a tool for data processing.
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Modulo: 010216/1 - STATISTICA MEDICA
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MEDICAL CHEMISTRY AND BIOCHEMISTRY
Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines. Use of simple calculation to perform dilution of drugs.
APPLIED BIOLOGY
Provide fundamental knowledge on biological macromolecules, structure and function of the cell components, replication and transcription of DNA, RNA translation.
MEDICAL GENETICS
To provide the fundamental knowledge on the genetic basis of the transmission of hereditary characters.
To analyze the molecular mechanisms causing hereditary genetic diseases in individuals and families.
Understanding the inheritance mechanism of inherited genetic diseases by pedigree analysis.
APPLIED PHYSISC
Basic physical training able to tackle elementary solutions of physical problems in the curriculum of the degree course.
MEDICAL STATISTICS
The course is intended to teach basic concepts of descriptive and inferential statistics applied to the biomedical field.
The teaching program is designed to providing the basic knowledge for interpreting the main statistical results reported in scientific evidence.
COMPUTER SCIENCE AND SEMIAR OF COMPUTER SCIENCE
Provide the basics that make up the hardware and software elements of a computer system.
Learn to use an electronic spreadsheet as a tool for data processing.
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Modulo: 015421/1 - GENETICA MEDICA
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MEDICAL CHEMISTRY AND BIOCHEMISTRY
Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines. Use of simple calculation to perform dilution of drugs.
APPLIED BIOLOGY
Provide fundamental knowledge on biological macromolecules, structure and function of the cell components, replication and transcription of DNA, RNA translation.
MEDICAL GENETICS
To provide the fundamental knowledge on the genetic basis of the transmission of hereditary characters.
To analyze the molecular mechanisms causing hereditary genetic diseases in individuals and families.
Understanding the inheritance mechanism of inherited genetic diseases by pedigree analysis.
APPLIED PHYSISC
Basic physical training able to tackle elementary solutions of physical problems in the curriculum of the degree course.
MEDICAL STATISTICS
The course is intended to teach basic concepts of descriptive and inferential statistics applied to the biomedical field.
The teaching program is designed to providing the basic knowledge for interpreting the main statistical results reported in scientific evidence.
COMPUTER SCIENCE AND SEMIAR OF COMPUTER SCIENCE
Provide the basics that make up the hardware and software elements of a computer system.
Learn to use an electronic spreadsheet as a tool for data processing.
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Modulo: 015440/3 - BIOLOGIA APPLICATA
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MEDICAL CHEMISTRY AND BIOCHEMISTRY
Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines. Use of simple calculation to perform dilution of drugs.
APPLIED BIOLOGY
Provide fundamental knowledge on biological macromolecules, structure and function of the cell components, replication and transcription of DNA, RNA translation.
MEDICAL GENETICS
To provide the fundamental knowledge on the genetic basis of the transmission of hereditary characters.
To analyze the molecular mechanisms causing hereditary genetic diseases in individuals and families.
Understanding the inheritance mechanism of inherited genetic diseases by pedigree analysis.
APPLIED PHYSISC
Basic physical training able to tackle elementary solutions of physical problems in the curriculum of the degree course.
MEDICAL STATISTICS
The course is intended to teach basic concepts of descriptive and inferential statistics applied to the biomedical field.
The teaching program is designed to providing the basic knowledge for interpreting the main statistical results reported in scientific evidence.
COMPUTER SCIENCE AND SEMIAR OF COMPUTER SCIENCE
Provide the basics that make up the hardware and software elements of a computer system.
Learn to use an electronic spreadsheet as a tool for data processing.
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Modulo: 26804 - FISICA APPLICATA
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MEDICAL CHEMISTRY AND BIOCHEMISTRY
Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines. Use of simple calculation to perform dilution of drugs.
APPLIED BIOLOGY
Provide fundamental knowledge on biological macromolecules, structure and function of the cell components, replication and transcription of DNA, RNA translation.
MEDICAL GENETICS
To provide the fundamental knowledge on the genetic basis of the transmission of hereditary characters.
To analyze the molecular mechanisms causing hereditary genetic diseases in individuals and families.
Understanding the inheritance mechanism of inherited genetic diseases by pedigree analysis.
APPLIED PHYSISC
Basic physical training able to tackle elementary solutions of physical problems in the curriculum of the degree course.
MEDICAL STATISTICS
The course is intended to teach basic concepts of descriptive and inferential statistics applied to the biomedical field.
The teaching program is designed to providing the basic knowledge for interpreting the main statistical results reported in scientific evidence.
COMPUTER SCIENCE AND SEMIAR OF COMPUTER SCIENCE
Provide the basics that make up the hardware and software elements of a computer system.
Learn to use an electronic spreadsheet as a tool for data processing.
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Modulo: 26805 - INFORMATICA
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MEDICAL CHEMISTRY AND BIOCHEMISTRY
Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines. Use of simple calculation to perform dilution of drugs.
APPLIED BIOLOGY
Provide fundamental knowledge on biological macromolecules, structure and function of the cell components, replication and transcription of DNA, RNA translation.
MEDICAL GENETICS
To provide the fundamental knowledge on the genetic basis of the transmission of hereditary characters.
To analyze the molecular mechanisms causing hereditary genetic diseases in individuals and families.
Understanding the inheritance mechanism of inherited genetic diseases by pedigree analysis.
APPLIED PHYSISC
Basic physical training able to tackle elementary solutions of physical problems in the curriculum of the degree course.
MEDICAL STATISTICS
The course is intended to teach basic concepts of descriptive and inferential statistics applied to the biomedical field.
The teaching program is designed to providing the basic knowledge for interpreting the main statistical results reported in scientific evidence.
COMPUTER SCIENCE AND SEMIAR OF COMPUTER SCIENCE
Provide the basics that make up the hardware and software elements of a computer system.
Learn to use an electronic spreadsheet as a tool for data processing.
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Modulo: 53261 - SEMINARIO DI INFORMATICA
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MEDICAL CHEMISTRY AND BIOCHEMISTRY
Acquired knowledge: basic knowledge of structure and function and transformation of macromolecules by the human body; basic knowledge to understand physiological and pathological processes in healthy or disease conditions.
Skills: use of the acquired chemical-biochemical knowledge to tackle the study of other biomedical disciplines. Use of simple calculation to perform dilution of drugs.
APPLIED BIOLOGY
Provide fundamental knowledge on biological macromolecules, structure and function of the cell components, replication and transcription of DNA, RNA translation.
MEDICAL GENETICS
To provide the fundamental knowledge on the genetic basis of the transmission of hereditary characters.
To analyze the molecular mechanisms causing hereditary genetic diseases in individuals and families.
Understanding the inheritance mechanism of inherited genetic diseases by pedigree analysis.
APPLIED PHYSISC
Basic physical training able to tackle elementary solutions of physical problems in the curriculum of the degree course.
MEDICAL STATISTICS
The course is intended to teach basic concepts of descriptive and inferential statistics applied to the biomedical field.
The teaching program is designed to providing the basic knowledge for interpreting the main statistical results reported in scientific evidence.
COMPUTER SCIENCE AND SEMIAR OF COMPUTER SCIENCE
Provide the basics that make up the hardware and software elements of a computer system.
Learn to use an electronic spreadsheet as a tool for data processing. Prerequisites
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Modulo: 000061/1 - BIOCHIMICA
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Basic concepts of chemistry. Very basic knowledge of the structure of atoms, nature of chemical bonds and aggregation states of the matter.
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Modulo: 009824/2 - CHIMICA MEDICA
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Basic concepts of chemistry and math. Very basic knowledge of the structure of atoms, nature of chemical bonds, stoichiometry and aggregation states of the matter.
Basic knowledge of epidemiology and biostatistics.
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Modulo: 010216/1 - STATISTICA MEDICA
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Basic knowledge of epidemiology and biostatistics.
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Modulo: 015421/1 - GENETICA MEDICA
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Basic concepts of chemistry and math. Very basic knowledge of the structure of atoms, nature of chemical bonds, stoichiometry and aggregation states of the matter.
Basic knowledge of epidemiology and biostatistics.
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Modulo: 015440/3 - BIOLOGIA APPLICATA
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Basic concepts of chemistry and math. Very basic knowledge of the structure of atoms, nature of chemical bonds, stoichiometry and aggregation states of the matter.
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Modulo: 26804 - FISICA APPLICATA
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Basic concepts of chemistry and math. Very basic knowledge of the structure of atoms, nature of chemical bonds, stoichiometry and aggregation states of the matter.
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Modulo: 26805 - INFORMATICA
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None.
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Modulo: 53261 - SEMINARIO DI INFORMATICA
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None. Course programme
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Modulo: 000061/1 - BIOCHIMICA
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Structure and function of carbohydrates, lipids, amino acids and proteins. Hemoglobin and myoglobin. Enzymes. ATP and Metabolism with the different steps in energy extraction from nutrients. Localization of metabolic pathways in the cell. Coenzymes and main metabolic pathways.
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Modulo: 009824/2 - CHIMICA MEDICA
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MEDICAL CHEMISTRY
Atom constituents and radioactivity. Chemical bonds. Gas Laws. Solutions. Solubility of gases in liquids. Chemical equilibrium: Le Chatelier's principle and Mass Action Law. Acids, bases and salts. Buffer solutions, pH, Salt hydrolysis, Osmotic pressure and osmolarity: hyper-hypo,isotonic and saline solutions. Basic information on organic chemistry (only functional groups recognition).
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Modulo: 010216/1 - STATISTICA MEDICA
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MEDICAL STATISTICS
The course will be structured around the following topics:
1) Descriptive Statistics: central tendency and variability indexes.
2) The fundamentals of probability as applied to diagnostic tests and biomedical research.
4) Statistical inference: Interval estimates (confidence intervals) and hypothesis testing with applications and examples in clinical research.
6) Inference on categorical data: the main measures of association such as Odds Ratio (OR) and Relative Risk (RR).
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Modulo: 015421/1 - GENETICA MEDICA
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MEDICAL GENETICS
General concepts of genetics: genes, alleles, genotype, phenotype. Mendel's laws. Independent genes and
associated genes. Codominance and multiple allelia (examples: System AB0 and HLA). Genomic,
chromosomal and gene mutations with examples of associated pathologies. Mendelian transmission of
autosomal dominant, autosomal recessive and X-associated genetic diseases and transmission of
mitochondrial diseases. Analysis of family trees.
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Modulo: 015440/3 - BIOLOGIA APPLICATA
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APPLIED BIOLOGY
Biological macromolecules: carbohydrates, proteins, nucleic acids. Lipids and cell membranes. Replication and transcription of DNA; translation of RNA. Genetic code. Organization of the cell. Major differences between cells of prokaryotes and eukaryotes. Eukaryotic cell components: nucleus, nucleolus, rough and smooth endoplasmic reticulum, ribosomes, Golgi apparatus, lysosomes, mitochondria, centrioles, cytoskeleton. Chromatin structure. Euchromatin and heterochromatin. From DNA to chromosomes. Protein sorting and endocytosis in cellular compartments. Membranes and transport mechanisms. Mechanisms of cell signaling. Cell cycle. Mitosis. Meiosis.
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Modulo: 26804 - FISICA APPLICATA
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APPLIED PHYSICS
Introductory topics: definition of percentage difference, hints of trigonometry, right triangle theorem. Scientific notation, physical quantities, vectors, Cartesian representation of vectors, vector calculus.
Laws of dynamics.
Definition of work, work and kinetic energy, work and potential energy,
Conservation of energy, momentum: its conservation; moment of a force; rotation of a body. Levers (three types).
Examples of levers in the human body and in the health sector; fluids: definitions, continuity equation; Bernoulli's theorem, Stevin's principle.
Fluids: Pascal's principle, communicating vessels; capillaries, osmosis; Archimedes' thrust; application examples (sphygmomanometer). Definitions of temperature and heat. Specific heat. Temperature scales.
Mechanical equivalent of calorie. Thermal expansion. Thermometer. Waves: definition; some parameters and properties; sound waves. Stethoscope. Ultrasound. Electromagnetic waves: definition and their spectrum.
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Modulo: 26805 - INFORMATICA
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Data and information. Basic components and functions of a computer system. Data processing: algorithm. Binary encoding. Hardware components. Software components. Function, structure and types of an operating system. Application software. File. Data storage and mass storage. File System. Data protection. Computer security and web navigation.
Basic elements of the spreadsheet. Editing commands. Graphical, numerical and conditional formatting of cells. Formulas and main logical, statistical, mathematical functions. Charts.
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Modulo: 53261 - SEMINARIO DI INFORMATICA
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Exercises on the use of the spreadsheet.
Analysis of experimental data through the most common descriptive statistics functions. Sorting and filtering data. Pivot tables. Didactic methods
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Modulo: 000061/1 - BIOCHIMICA
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Lectures + Google Classroom use for communications, exercises and store of useful material.
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Modulo: 009824/2 - CHIMICA MEDICA
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Lectures + hands-on computer lab
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Modulo: 010216/1 - STATISTICA MEDICA
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Lectures
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Modulo: 015421/1 - GENETICA MEDICA
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Lectures
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Modulo: 015440/3 - BIOLOGIA APPLICATA
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Lectures + hands-on computer lab
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Modulo: 26804 - FISICA APPLICATA
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Lectures + hands-on computer lab
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Modulo: 26805 - INFORMATICA
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Lectures.
NB: if you have it, is suggested to bring a laptop to the lectures.
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Modulo: 53261 - SEMINARIO DI INFORMATICA
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Lectures (no computer lab).
NB: if you have it, is suggested to bring your own personal PC. Learning assessment procedures
- MEDICAL CHEMISTRY
Multiple-choice written test (4 possible answers) composed by 11 questions about the subjects of the course. Starting points: 10. Each correct answer scores 2 points; no penalties for wrong or not answered question. To pass the exam, it is necessary to score at least 8 points (4 questions), corresponding to 18/30. The final score corresponds to the final grade of the exam. The time allowed is 15 minutes.
BIOCHEMISTRY
Multiple-choice written test (3-4 possible answers with only one correct) composed by 18 questions about the subjects of the course. Each correct answer scores 2 points; no penalties for wrong or not answered question. To pass the exam, it is necessary to score at least 18 points (9 correct answers), corresponding to 18/30 as final grade of the exam. Maximal grade 31 with all correct answers. The time allowed is 30 minutes.
BIOLOGY
Written multiple choice exam.
GENETICS
Learning assessment procedures
Written test, with the administration of 10 multiple choice questions (3-4 options). Each correct answer
corresponds to 3 points, wrong answers are worth 0 points. Total time available: 30 minutes.
APPLIED PHYSICS
A written examination with 18 multiple choice quizzes, each with five possible answers. Valuation: each correct answer two point; answer not given zero points. -0.5 for each wrong answer. The vote obtained will be converted into thirtieths. Duration: 30 minutes.
MEDICAL STATISTICS
A written examination with closed-ended questions.
COMPUTER SCIENCE AND COMPUTER SEMINAR
Written exam consisting of 30 multiple choice questions (with 1 correct answer) divided into 2 macro-topics: Basic computer science 15 questions; Spreadsheet 15 questions.
Rating:
1 point for correct answer
0 points for wrong or undated answer.
Duration: 30 minutes.
The exam is considered passed only if, regardless of the overall score achieved, at least 9 answers are correct for each macro-topic
THE FINAL GRADE IS A ARITHMETIC AVERAGE OF THE MARKS OBTAINED IN EACH TESTS. Reference texts
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Modulo: 000061/1 - BIOCHIMICA
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-Every Biochemistry text can go however synthetic texts are suggested, such as
M. Stefani, N. Taddei, Chemistry, Biochemistry and Applied Biology, Ed Zanichelli or Stefani e Taddei, Chemistry and Biochemistry, Ed Zanichelli.
Otherwise Catani ecc. Appunti di Biochimica, Piccin ed. or Samaja e Paroni, Chimica e Biochimica, Piccin Ed or Bertoldi ecc., Chimica e Biochimica, EdiSES.
+teaching materials provided by teachers.
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Modulo: 009824/2 - CHIMICA MEDICA
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MEDICAL CHEMISTRY
M. Stefani, N. Taddei, Chemistry, Biochemistry and Applied Biology, Ed Zanichelli and teaching materials provided by teachers.
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Modulo: 010216/1 - STATISTICA MEDICA
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MEDICAL STATISTICS
• Martin Bland, Statistica Medica, Apogeo Ed. 2009.
• Marcello Pagano, Kimberlee Gauvreau, Fondamenti di Biostatistica, Idelson Gnocchi 2003.
• Bernard Rosner, Fundamentals of Biostatistics, Cengage Learning 2011.
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Modulo: 015421/1 - GENETICA MEDICA
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GENETICS
Neil A., Campbell, Jane B. Reece, Biologia- La genetica, Zanichelli Ed.
M.R. Cummings,Eredità, EdiSES
B. A. Pearce, Genetica, Zanichelli Ed.
Alternatively, after consultation with the teacher, any updated text of Genetics
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Modulo: 015440/3 - BIOLOGIA APPLICATA
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APPLIED BIOLOGY
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Modulo: 26804 - FISICA APPLICATA
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APPLIED PHYSICS
Monaco, R. Sacchi, A. Solano, Elements of Physics, McGraw Hill and lecture notes by the teacher
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Modulo: 26805 - INFORMATICA
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None, not needd. The slides cover all the arguments.
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Modulo: 53261 - SEMINARIO DI INFORMATICA
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None.
