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ADVANCED DIAGNOSTIC OF ENDOCRINE NEOPLASIA

Academic year and teacher
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Versione italiana
Academic year
2022/2023
Teacher
MARIA CHIARA ZATELLI
Credits
2
Didactic period
Secondo Semestre
SSD
MED/13

Training objectives

Provide knowledge on the diagnosis and the molecular mechanisms and clinical management of endocrine neoplasms.
The main acquired knowledge will be:
-molecular mechanisms of multiple endocrine neoplasias, neuroendocrine tumors and endocrine diseases due to molecular damages
-clinical, biochemical and instrumental diagnostic approach to neuroendocrine neoplasms
-therapeutic approach to neuroendocrine neoplasms
The basic acquired abilities will be:
-To know which molecular investigations can be performed in the settings of specific endocrine diseases
-To interpret correctly a report dealing with molecular diagnostics of specific endocrine diseases
-Knowledge of the clinical management of the neuroendocrine neoplasms
-Acquisition of skillfulness for interdisciplinary working

Prerequisites

Background knowledge in anatomy, biology, physiology and physiopathology of the endocrine system.
Background knowledge in biochemistry and molecular biology of hormone mechanism of action.

Course programme

The course forecasts 16 hours of teaching. During this time, examples of molecular diagnostics of endocrine diseases mechanisms carried on at the Endocrine Lab will also be offered to the students.
Molecular diagnostics of thyroid nodules.
Molecular basis of endocrine neoplasms.
Familial forms of pituitary adenomas.
Pituitary side effects of oncological therapy.
RET mutation analysis in Endocrinology.
MEN4.
Classification of neuroendocrine neoplasms.
Neuroendocrine neoplasms of the gastro-entero-pancreatic system: clinical picture, diagnosis and therapeutic approach.
Neuroendocrine neoplasms of the lung: clinical picture, diagnosis and therapeutic approach
Pheochromocytoma and paranganglioma: clinical picture, diagnosis and therapeutic approach.

Didactic methods

Frontal lectures on all the course’s topics;
interdisciplinary seminars with presentation and discussion of clinical cases
visits to the Endocrine Physiopathology at the Section of Endocrinology and Internal Medicine, Dept. of Medical Sciences of the University of Ferrara at the Hospital of Ferrara, Via Aldo Moro 8, Cona - Ferrara. After the guided tutorials the students will have free access to the lab for additional individual tests.
Online teaching might be necessary.

Learning assessment procedures

The aim of the exam is to verify at which level the learning objectives previously described have been acquired, by a test lasting 1 hour with 31 questions displaying 4 possible answers (only one is correct); each correct answer is equivalent to 1 point, while each wrong or blank answer is 0 points. The test will evaluate the acquired knowledge and the capacity of connecting the acquired notions. To pass this test it is required to get at least 18 points out of 30

Reference texts

Specific topics can be further developed in an Endocrinology text (Faglia G., Beck-Peccoz P., Spada A., Malattie del sistema endocrino e del metabolismo, V edizione, McGraw -Hill, Italia 2013; Monaco F., Endocrinologia Clinica. V edizione anno 2011, Società Editrice Universo- Roma)