FORENSIC MEDICINE, GENERAL PHARMACOLOGY AND DOPING
Academic year and teacher
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- Versione italiana
- Academic year
- 2019/2020
- Teacher
- STEFANIA MERIGHI
- Credits
- 9
- Didactic period
- Primo Semestre
Training objectives
- GENERAL PHARMACOLOGY AND DOPING
Training objectives
The main goal of the course consists in providing basic knowledges of General Pharmacology related to Pharmacokinetics and Pharmacodynamics. Moreover, the course aims to provide the basic elements for understanding the mechanisms of drug action, the therapeutic index and the drug toxicity. The pharmacological effects of some of the most important drugs used in the life and in the pain therapy will be assessed.
The main knowledge acquired will be:
- general concepts of pharmacokinetics
- general concepts of pharmacodynamics
- mechanisms of drug action, correlation with different classes of the receptors and evaluation of the drug effects in some cardiovascular and neurodegenerative pathologies
-the classification of the main classes of drugs and methods prohibited in sport
The basic acquired abilities (that are the capacity of applying the acquired knowledge) will be:
-assessment of pharmacokinetic factors determining drug effects, drug mechanisms and toxicity to better clarify the pharmacological effect of the drugs
-knowledge of the cellular and molecular mechanisms at the basis of the drug effects.
-to analyze the programme of research and development of new drugs
-to evaluate the possibility of drug therapy to be applied in sports
-to examine critically the new types of alternative medicines on the market Prerequisites
- GENERAL PHARMACOLOGY AND DOPING
Basic knowledge of chemistry, biochemistry, physiology, anatomy and biology are requested. Course programme
- GENERAL PHARMACOLOGY AND DOPING
The course forecasts 48 hours of teaching through frontal lectures divided as follows:
- General principles of Pharmacokinetics and Pharmacodynamics (2 hours)
- Drug research and development (2 hours)
- Pharmacokinetics: administration routes; absorption; distribution; metabolism; excretion; bioavailability (8 hours)
- Drug-receptor interaction and dose-response curves (4 hours)
- Agonists, antagonists and allosteric modulators (4 hours)
- Therapeutic index and drug toxicity (4 hours)
- Classification of the receptors (2 hours)
- Mechanism of the drug-receptor interaction (2 hours)
- Main drugs primarily used e.g. benzodiazepines, NSAIDs and opioids (4 hours)
- The drugs in the most common cardiovascular and neurodegenerative diseases (4 hours)
-Generic drugs and homeopathic remedies (2 hours)
-The main classes of biotechnological drugs (2 hours)
-Doping, prohibited list (WADA): Stimulants, narcotics, anabolic agents, Diuretics, Corticosteroids, Antiasthmatic agents (8 hours) Didactic methods
- GENERAL PHARMACOLOGY AND DOPING
Frontal lectures on the course’s topics through power point presentation. Learning assessment procedures
- The aim of the exam is to verify at which level the learning objectives previously described have been acquired. The aim of this examination is to evaluate how deeply the student has studied the subject and how he is able to understand the basic topics analyzed. The exam is based on 31 multiple choice questions with four answers each; the question is worth one point if correct, wrong answer or no answer 0 points. To pass this test it is required to get at least 18 points. The time allowed for this test is 1 hour.
Reference texts
- GENERAL PHARMACOLOGY AND DOPING
Mottram D.R., Farmaci e sport, Casa Ed. Ambrosiana
Rossi F., Cuomo V., Riccardi G., Farmacologia. Principi di base e applicazioni terapeutiche, Ed. Minerva Medica
Power point presentation of the lessons
