INTEGRATED COURSE OF BIOLOGY
Academic year and teacher
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- Versione italiana
- Academic year
- 2022/2023
- Teacher
- ANNALAURA MANCIA
- Credits
- 12
- Didactic period
- Primo Semestre
Training objectives
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Modulo: 000069 - BIOLOGIA GENERALE
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This course focuses on the basic concepts of the biology of the cell and it is a combination of two major parts, namely General Biology and Cell Biology. The main goal is to drive the students towards the understanding of the molecular basis of cellular organization and function.
The student will learn necessary notions about prokaryotic and eukaryotic cells, on the structure and function of the cell compartments, on energy metabolism, on the flow of the genetic information, on cell division and on the specific methodologies to study the biology of the cell in any environment. Cell death, cell proliferation and transformation will also be discussed, together with the origin of life and the evolution of the cell and the general characteristics of the five Kingdoms system of classification for living organisms.
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Modulo: 004662 - BIOLOGIA CELLULARE
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This course focuses on the basic concepts of the biology of the cell and it is a combination of two major parts, namely General Biology and Cell Biology. The main goal is to drive the students towards the understanding of the molecular basis of cellular organization and function.
The student will learn necessary notions about prokaryotic and eukaryotic cells, on the structure and function of the cell compartments, on energy metabolism, on the flow of the genetic information, on cell division and on the specific methodologies to study the biology of the cell in any environment. Cell death, cell proliferation and transformation will also be discussed, together with the origin of life and the evolution of the cell and the general characteristics of the five Kingdoms system of classification for living organisms. Prerequisites
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Modulo: 000069 - BIOLOGIA GENERALE
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No formal preparatory studies are mandatory. However, basic concepts and knowledge of biology provided by high-school courses are needed.
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Modulo: 004662 - BIOLOGIA CELLULARE
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No formal preparatory studies are mandatory. However, basic concepts and knowledge of biology provided by high-school courses are needed. Course programme
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Modulo: 000069 - BIOLOGIA GENERALE
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GENERAL BIOLOGY. Introduction to
biology and methods of study. Prokaryotic and eukaryotic cell. Chemical components of cellular structures. Biological macromolecules: proteins, carbohydrates, lipids and nucleic acids. The biological membranes. The discovery of DNA and its organization within the prokaryotic and eukaryotic cell. The nucleus of the eukaryotic cell. DNA replication and transcription. Translation of genetic information. Regulation of gene expression. Cell cycle. Structure of chromosomes. Mitosis and meiosis. Male and female gametogenesis. Sexual reproduction, fertilization and asexual reproduction. Mutations. The biology of cancer. DNA, RNA and retroviruses. The genome and study techniques. The technique of PCR and gene editing.
CELL BIOLOGY. The living Kingdoms: concept of species, principles of classification and taxonomical ranks. General characteristics of living organisms: evolution, complexity, cell organization, nutrition, metabolism and variability of Prokaryotes, Protista, Fungi, Plants and Animals.
Main instruments and techniques for morphological studies. Light and electron microscopes. Tissue preparation: dissection, fixation, embedding, cut (microtome and cut planes), histological staining, observation of slide sections. Cito-histochemistry, immunohistochemistry and immunofluorescence. Cell morphology, organization and function of the main components. Cytoskeleton, extracellular matrix and cell junctions. The endomembrane system and membrane trafficking. Cell metabolism and energy storage. Signal transduction and cellular communication. Tissue homeostasis: proliferation (stem cells), repair, cell death. Main tissues and their functions.
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Modulo: 004662 - BIOLOGIA CELLULARE
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GENERAL BIOLOGY. Introduction to biology and methods of studying life. Origin of life on the planet, origin of the cell and subdivision of living beings. The organization of living beings at biological macromolecule level: carbohydrates and lipids, amino acids and proteins, nucleotides and nucleic acids. Function of the prokaryotic and eukaryotic cells. DNA replication. The transmission of genetic information: the genetic code and transcription. Translation and protein synthesis. Control of gene expression. Mitosis, meiosis and gametogenesis. Embryonic development, types of eggs and stages of development in animals. Biology of the transformed cell. DNA, RNA and retroviruses. The main model organisms of biotechnological and biomedical interest and their genomes.
CELL BIOLOGY. The living Kingdoms: concept of species, principles of classification and taxonomical ranks. General characteristics of living organisms: evolution, complexity, cell organization, nutrition, metabolism and variability of Prokaryotes, Protista, Fungi, Plants and Animals.
Main instruments and techniques for morphological studies. Light and electron microscopes. Tissue preparation: dissection, fixation, embedding, cut (microtome and cut planes), histological staining, observation of slide sections. Cito-histochemistry, immunohistochemistry and immunofluorescence. Cell morphology, organization and function of the main components. Cytoskeleton, extracellular matrix and cell junctions. The endomembrane system and membrane trafficking. Cell metabolism and energy storage. Signal transduction and cellular communication. Tissue homeostasis: proliferation (stem cells), repair, cell death. Main tissues and their functions. Didactic methods
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Modulo: 000069 - BIOLOGIA GENERALE
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The course includes 48 hours of lectures for General Biology Topics will be discussed with the assistance of PowerPoint slides using reference texts integrated with the most recent published works. Every other week on line meetings will be scheduled for further explanations and/or questions.
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Modulo: 004662 - BIOLOGIA CELLULARE
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The course includes 48 hours of lectures for General Biology (6 CFU) and 48 hours of lectures for Cell Biology (6 CFU) for a total of 96 hours and 12 CFU. Topics will be discussed with the assistance of PowerPoint slides using reference texts integrated with the most recent published works. Learning assessment procedures
- The purpose of the final test will be to verify the knowledge of the topics of the course. The test is composed of 31 multiple-choice questions. Each correct answer has a value of 1/30, for a total of 31 points, corresponding to a maximum score of 30/30 magna cum laude. To pass the test, the student must answer correctly to at least 18 questions (score 18/30). The student will have 40 minutes to complete the test. The test could be delivered through online platforms such as Google Meet.
For DSA students, the procedure and the duration of the test will be evaluated individually. Reference texts
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Modulo: 000069 - BIOLOGIA GENERALE
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GENERAL BIOLOGY
1. Autori Vari, a cura di De Leo, Ginelli e Fasano – Biologia e Genetica – Edizione EdiSES, 2020 – ISBN: 978-88-3623-001-3.
2. D. Sadava, D.M. Hillis, H.C. Heller, S. Hacker - Biologia - Edizioni Zanichelli, 2019.
- Volume 1 - La cellula - ISBN: 978-88-08-33859-4
- Volume 2 - L'ereditarietà e il genoma - ISBN: 978-88-08-95528-9.
CELL BIOLOGY
4. G. Plopper, a cura di Aldo Pagano. Principi di Biologia della cellula. Zanichelli. ISBN: 978-88-08-42128-9 (english version: G. Plopper. Principles of Cell Biology. Second Edition. ISBN: 978-1284047608).
5. D. Sadava, D.M. Hillis, H.C. Heller, S. Hacker - Biologia - Edizioni Zanichelli, 2019. Volume 3. L’evoluzione e la biodiversità – Pagine 352; ISBN: 978-88-08-289650.
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Modulo: 004662 - BIOLOGIA CELLULARE
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GENERAL BIOLOGY
1. Autori Vari, a cura di De Leo, Ginelli, e Fasano. Biologia e Genetica, 4a EDIZIONE. Editore EdiSES, Napoli.
2. D. Sadava, D.M. Hillis, H.C. Heller, S. Hacker - Biologia - Edizioni Zanichelli, 2019.
- Volume 1 - La cellula - Pagine 256 ISBN: 978-88-08-33859-4
- Volume 2 - L'ereditarietà e il genoma - Pagine 264 ISBN: 978-88-08-95528-9
- Volume 3- L'evoluzione e la biodiversità - Pagine 352 ISBN: 978-88-08-289650 (testo facoltativo)
3. B. Alberts, et al. - Biologia molecolare della cellula - Ed. Zanichelli, Bologna.
CELL BIOLOGY
4. G. Plopper, a cura di Aldo Pagano. Principi di Biologia della cellula. Zanichelli. ISBN: 978-88-08-42128-9 (english version: G. Plopper. Principles of Cell Biology. Second Edition. ISBN: 978-1284047608).
5. D. Sadava, D.M. Hillis, H.C. Heller, S. Hacker - Biologia - Edizioni Zanichelli, 2019. Volume 3. L’evoluzione e la biodiversità – Pagine 352; ISBN: 978-88-08-289650.
