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INTEGRATED COURSE OF CHEMISTRY

Academic year and teacher
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Versione italiana
Academic year
2022/2023
Teacher
PAOLO MARCHETTI
Credits
12
Didactic period
Primo Semestre

Training objectives

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Modulo: 000148/1 - CHIMICA ORGANICA
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ORGANIC CHEMISTRY
The training objective of organic chemistry course are focused on the properties and reactivity of the major organic chemistry compound classes and their interactions with the biological systems. In particular students must known the following concept:
1) Preparation, reactivity and nomenclature of alkenes.
2) Preparation, reactivity and nomenclature of alkynes.
3) Preparation, reactivity and nomenclature of alcohols.
4) Preparation, reactivity and nomenclature of aldehydes and ketones.
5) Preparation, reactivity and nomenclature of amines.
6) Preparation, reactivity and nomenclature of carboxylic acid.
7) Preparation, reactivity and nomenclature of aromatic compounds.
8) Preparation, reactivity and nomenclature of carboxylic acid derivatives: esters, amides, anhydrides, acylic halogenides, lactons and lactams.
9) Nucleophilic substitutions at saturated carbon (Sn1 and Sn2), Elimination reactions, E1 and E2.
10) Sugars properties and reactivity in particular for mono and di saccarides.
11) Chemical properties and biological interactions of aminoacids.
12) Chemical properties and biological interactions of DNA bases and basic heterocyclic chemistry.
13) Stereochemistry aspects
At the end of the course the students must be recognize the main class of organic compounds and their reactivity, in particular natural organic compounds such as sugar, amino acid, proteins and DNA bases.

GENERAL AND INORGANIC CHEMISTRY
The course of General and Inorganic Chemistry is mainly aimed to provide students the basic concepts of chemistry for a full comprehension of the contents of the next, and more dedicated, chemistry courses.
The main acquired knowledges will be on atomic structure, arrangement of the elements in the periodic table, periodic properties, relationship between chemical reactivity and groups/valence electronic configurations, chemical bonding, type of reactions and their balancing, properties of gaseous and liquid compounds/mixtures, properties of solutions and their concentrations, dilution, chemical equilibrium, acid-base equilibria.
At the end of this course, the student will be able to identify and the most important classes of inorganic compounds. He/she will also be able to predict their chemical formula, main properties, chemical structure. Students will learn how to balance chemical reactions as well as calculating the amount of reagents and products at the equilibrium. Besides, student will be able to carry out experiments at the macroscopic level, to think at a microscopic level and to translate observed results in a symbolic language.

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Modulo: 013860 - CHIMICA GENERALE ED INORGANICA
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ORGANIC CHEMISTRY
The training objective of organic chemistry course are focused on the properties and reactivity of the major organic chemistry compound classes and their interactions with the biological systems. In particular students must known the following concept:
1) Preparation, reactivity and nomenclature of alkenes.
2) Preparation, reactivity and nomenclature of alkynes.
3) Preparation, reactivity and nomenclature of alcohols.
4) Preparation, reactivity and nomenclature of aldehydes and ketones.
5) Preparation, reactivity and nomenclature of amines.
6) Preparation, reactivity and nomenclature of carboxylic acid.
7) Preparation, reactivity and nomenclature of aromatic compounds.
8) Preparation, reactivity and nomenclature of carboxylic acid derivatives: esters, amides, anhydrides, acylic halogenides, lactons and lactams.
9) Nucleophilic substitutions at saturated carbon (Sn1 and Sn2), Elimination reactions, E1 and E2.
10) Sugars properties and reactivity in particular for mono and di saccarides.
11) Chemical properties and biological interactions of aminoacids.
12) Chemical properties and biological interactions of DNA bases and basic heterocyclic chemistry.
13) Stereochemistry aspects
At the end of the course the students must be recognize the main class of organic compounds and their reactivity, in particular natural organic compounds such as sugar, amino acid, proteins and DNA bases.

GENERAL AND INORGANIC CHEMISTRY
The course of General and Inorganic Chemistry is mainly aimed to provide students the basic concepts of chemistry for a full comprehension of the contents of the next, and more dedicated, chemistry courses.
The main acquired knowledges will be on atomic structure, arrangement of the elements in the periodic table, periodic properties, relationship between chemical reactivity and groups/valence electronic configurations, chemical bonding, type of reactions and their balancing, properties of gaseous and liquid compounds/mixtures, properties of solutions and their concentrations, dilution, chemical equilibrium, acid-base equilibria.
At the end of this course, the student will be able to identify and the most important classes of inorganic compounds. He/she will also be able to predict their chemical formula, main properties, chemical structure. Students will learn how to balance chemical reactions as well as calculating the amount of reagents and products at the equilibrium. Besides, student will be able to carry out experiments at the macroscopic level, to think at a microscopic level and to translate observed results in a symbolic language.

Prerequisites

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Modulo: 000148/1 - CHIMICA ORGANICA
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ORGANIC CHEMISTRY
Fundamental concepts of general and inorganic chemistry.

GENERAL AND INORGANIC CHEMISTRY
Basic knowledge of mathematics and physics is required: equations, skills in the graphic description of simple mathematical functions, logarithms, exponential calculus, units of measure. No preliminary rules are present.

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Modulo: 013860 - CHIMICA GENERALE ED INORGANICA
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ORGANIC CHEMISTRY
Fundamental concepts of general and inorganic chemistry.

GENERAL AND INORGANIC CHEMISTRY
Basic knowledge of mathematics and physics is required: equations, skills in the graphic description of simple mathematical functions, logarithms, exponential calculus, units of measure. No preliminary rules are present.

Course programme

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Modulo: 000148/1 - CHIMICA ORGANICA
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ORGANIC CHEMISTRY: Structure and bonding. Constitutional isomers. Lewis and Bronsted-Lowry’s acid and bases. (4 hrs)
Carbon atoms hybridization. Reactivity, nomenclature and preparation of alkanes, cycloalkanes, alkenes, alkynes, alcohols, aldehydes, ketones, carboxylic acid and derivatives, Amine and derivatives. (10 hrs)
Alchilalides and the nucleophilic substitution: SN1, SN2, elimination reactions, E1 and E2. Epoxides and ring opening reactions in acidic and basic conditions. (8 hrs)
The Zaitsev’s rule and the cis/trans E/Z isomery in alkenes and cycloalkanes. The Markovnikov’s rule and the alcohols elimination. (4 hrs)
Aromatic chemistry, electrophylic aromatic substitutions, Huckel’s rule, Friedel and Crafts reactions. Carboxylic acid and their derivatives, the Fischer esterification. Grignard’s reagents and the reactivity of the carbonyl group. (10 hrs)
Sugar, structure and functions, the anomeric effect. Amino acids and peptides, peptidic bond. Stereochemistry and R/S rule, geometric and constitutionals isomers. Nucleotides and nucleoside as a DNA bases. (12 hrs)
GENERAL AND INORGANIC CHEMISTRY
The course consists of 48 hours of lessons.
The subjects of the lessons will be:
1) Atoms and elements; composition of matter; periodic table of the elements and periodic properties; atomic and molecular weights; mole (10 hrs)
2) Chemical bond. Main classes of compounds (10 hrs)
3) Gas laws. Liquids and solids. Solutions. Colligative properties (8 hrs)
4) Chemical reactions. Stoichiometry. Chemical equilibrium. Principles of Thermochemistry (10 hrs)
5) Acids and bases: pH, hydrolysis, buffered solutions (12 hrs)
6) Principles of electrochemistry (2 hrs)



------------------------------------------------------------
Modulo: 013860 - CHIMICA GENERALE ED INORGANICA
------------------------------------------------------------
ORGANIC CHEMISTRY: Structure and bonding. Constitutional isomers. Lewis and Bronsted-Lowry’s acid and bases. (4 hrs)
Carbon atoms hybridization. Reactivity, nomenclature and preparation of alkanes, cycloalkanes, alkenes, alkynes, alcohols, aldehydes, ketones, carboxylic acid and derivatives, Amine and derivatives. (10 hrs)
Alchilalides and the nucleophilic substitution: SN1, SN2, elimination reactions, E1 and E2. Epoxides and ring opening reactions in acidic and basic conditions. (8 hrs)
The Zaitsev’s rule and the cis/trans E/Z isomery in alkenes and cycloalkanes. The Markovnikov’s rule and the alcohols elimination. (4 hrs)
Aromatic chemistry, electrophylic aromatic substitutions, Huckel’s rule, Friedel and Crafts reactions. Carboxylic acid and their derivatives, the Fischer esterification. Grignard’s reagents and the reactivity of the carbonyl group. (10 hrs)
Sugar, structure and functions, the anomeric effect. Amino acids and peptides, peptidic bond. Stereochemistry and R/S rule, geometric and constitutionals isomers. Nucleotides and nucleoside as a DNA bases. (12 hrs)
GENERAL AND INORGANIC CHEMISTRY
The course consists of 48 hours of lessons.
The subjects of the lessons will be:
1) Atoms and elements; composition of matter; periodic table of the elements and periodic properties; atomic and molecular weights; mole (10 hrs)
2) Chemical bond. Main classes of compounds (10 hrs)
3) Gas laws. Liquids and solids. Solutions. Colligative properties (8 hrs)
4) Chemical reactions. Stoichiometry. Chemical equilibrium. Principles of Thermochemistry (10 hrs)
5) Acids and bases: pH, hydrolysis, buffered solutions (12 hrs)
6) Principles of electrochemistry (2 hrs)


Didactic methods

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Modulo: 000148/1 - CHIMICA ORGANICA
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ORGANIC CHEMISTRY
48 Lectures in classroom, using the blackboard, power point slides for the molecular orbitals lessons and 3D models to better understand the stereochemistry aspect of the molecules.

GENERAL AND INORGANIC CHEMISTRY
The course consists of 48 hours of lectures about all the topics. Numerical exercises will be performed in order to favour understanding.

------------------------------------------------------------
Modulo: 013860 - CHIMICA GENERALE ED INORGANICA
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ORGANIC CHEMISTRY
48 Lectures in classroom, using the blackboard, power point slides for the molecular orbitals lessons and 3D models to better understand the stereochemistry aspect of the molecules.

GENERAL AND INORGANIC CHEMISTRY
The course consists of 48 hours of lectures about all the topics. Numerical exercises will be performed in order to favour understanding.

Learning assessment procedures

ORGANIC CHEMISTRY
1. EXAMINATION METHOD
The exam relating to the integrated courses can be taken in two ways:
(a) By taking the exams relating to the individual modules that make up the Integrated Course separately. This modality is offered in order to support the study needs of the students of the course by dividing the study effort into partial tests concerning the two disciplines that make up the Integrated Course.
It provides:
Organic Chemistry module. Duration 35 minutes
General and Inorganic Chemistry Module. Duration 60 minutes
In this case, the final exam mark derives from the average of the marks obtained in the two modules.
The verbalization of the exam score takes place according to the methods described in point 2.
(b) On a single date when the exam refers to the program of the entire integrated course (ie referring to the two modules that make it up). This method is provided upon request by the student.
It includes Organic Chemistry + General and Inorganic Chemistry. Duration 35 + 60 = 95 minutes total. In this case, the verbalization takes place directly from the exam registration session with a request for acceptance/rejection of the grade.
2. REPORTING OF THE INTEGRATED COURSE EXAMINATION TAKEN IN METHOD (a)
1) PARTIAL TEST (indicated with a P): corresponds to the tests of the individual modules of the integrated course.
• The outcome of these tests will not automatically be recorded in the student's virtual booklet and does not require acceptance/rejection.
• If the student presents himself at a subsequent appeal to take this test again, the outcome of the last test will be considered for the purposes of the verbalisation.
• In the case of an integrated course, after passing all the tests of the modules that make it up, the student will have to register for the verbalization session (see point 2).
2) VERBALIZATION CALL (indicated with a globe): corresponds to the verbalization of an integrated course for which all the partial tests/modules have been passed.
• The teacher responsible for recording the Integrated Course in each session will publish exam sessions for verbalization only in which the student MUST register.
• In the event that a student wants to improve the mark of one or more modules, he must NOT register for the verbalization session.
• The final grade of the Integrated Course is the average of the grades achieved in the individual modules.
The final grade of the Integrated Course will be recorded in the student's virtual booklet upon acceptance by the student.
• Positive assessments of individual modules do not have a validity date.
• The verbalization of the exam takes place online (presence is not necessary).
• Once an exam has been registered, it can no longer be repeated. Therefore it is advisable to record the grade of an exam only when you are sure that you accept the grade.

GENERAL AND INORGANIC CHEMISTRY
The exam is written, in the form of a multiple choice test. The maximum time is 50 minutes.
The test consists of 13 questions, either of theorethical or numerical character. The evaluation will be made as follows: 3 points for questions 1-10, 1 point for questions 11-13. The Student is allowed to use the periodic table, and a calculating machine.
The mark will be communicated to the Student at the institutional email address. In case of positive evaluation, the Student shall access the personal webpage (@ studiare.unife.it) and proceed with acceptance/decline of the mark.

Reference texts

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Modulo: 000148/1 - CHIMICA ORGANICA
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ORGANIC CHEMISTRY

- A copy of the handout written by the teacher, updated for the year of course 2022-2023 and available at the copy shop. The latter are sufficient to pass the final test with full marks.

Any supporting books:

- Janice Gorzynski Smith, Second Edition, Fondamenti di Chimica Organica, McGraw-Hill.


GENERAL AND INORGANIC CHEMISTRY
The topics of the course can be found in the following books:

“Chimica - Un approccio molecolare”, Nivaldo J. Tro, EdiSES editore, nuova edizione.
“Chimica”, J. Kotz, J. Townsend, D. Treichel, P. Treichel, EdiSES editore, nuova edizione.

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Modulo: 013860 - CHIMICA GENERALE ED INORGANICA
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ORGANIC CHEMISTRY
- Janice Gorzynski Smith, Second Edition, Fondamenti di Chimica Organica, McGraw-Hill.
- Handout recommended by the teacher available at the copy shop

GENERAL AND INORGANIC CHEMISTRY
The topics of the course can be found in the following books:

“Chimica - Un approccio molecolare”, Nivaldo J. Tro, EdiSES editore, nuova edizione.
“Chimica”, J. Kotz, J. Townsend, D. Treichel, P. Treichel, EdiSES editore, nuova edizione.